Morais Paulo, Baudrier Teresa, Santos António, Mota Alberto, Duarte Ana Filipa, Ventura Jesus, Azevedo Filomena
Department of Dermatovenereology, Hospital S. João, Alameda Professor Hernâni Monteiro, Porto, Portugal.
Acta Dermatovenerol Alp Pannonica Adriat. 2011;20(4):221-4.
Paraneoplastic syndromes (PS) are diseases or symptom complexes associated with malignancy, usually of internal origin, but not directly related to mass effects, invasion, or metastatic spread. Rarely, cutaneous squamous cell carcinoma (SCC) may be associated with PS. We present a patient with a giant SCC located on the right leg and a pheochromocytoma. Considering the concurrent onset and parallel course of both pheochromocytoma and SCC in this patient, and the complete resolution of the endocrine abnormalities after resection of the skin tumor, it was possible to conceive of the pheochromocytoma as a paraneoplastic phenomenon. To our knowledge, this association has not been previously described.
副肿瘤综合征（PS）是与恶性肿瘤相关的疾病或症状复合体，通常起源于体内，但与肿块效应、侵袭或转移扩散无直接关系。皮肤鳞状细胞癌（SCC）很少与副肿瘤综合征相关。我们报告一例患者，其右腿有巨大SCC并伴有嗜铬细胞瘤。考虑到该患者嗜铬细胞瘤和SCC同时发病且病程平行，以及皮肤肿瘤切除后内分泌异常完全缓解，有可能将嗜铬细胞瘤视为一种副肿瘤现象。据我们所知，这种关联此前尚未见报道。
