Laboratório de Microbiologia Clínica, Ciências da Saúde, Centro Universitário Franciscano, UNIFRA, Rua dos Andradas 1614, sala 115, 97010-032, Santa Maria, Rio Grande do Sul, Brazil.
Inflammation. 2012 Aug;35(4):1256-61. doi: 10.1007/s10753-012-9436-7.
Due to the fact that an increased number of patients have experienced bloodstream infections caused by Candida species and the high mortality of this infection, there is a need for a strategy to reduce this scenery. One possible strategy is the use of new drugs, such as fructose-1,6-bisphosphate (FBP), which is a high-energy glycolytic metabolite and has shown to have therapeutic effects in several pathological conditions such as ischemia, shock, toxic injuries, and bacterial sepsis. The aim of this manuscript was to determine the role of FBP in experimental Candida albicans bloodstream infection. We used mice that were divided into three experimental groups: sham (not induced), bloodstream infection (induced with intratracheal instillation of C. albicans) and FBP (bloodstream infection plus FBP 500 mg/kg i.p.). Blood was taken for assessment of complete hematological profile and cytokine assay (IL-6 and MCP-1). Results of the study demonstrated that mortality decreased significantly in groups that received FBP. All cytokine and hematological indexes of FBP group were similar to bloodstream infection group with exception of platelets count. FBP significantly prevented the decrease in platelets. Taken together, our results demonstrate that FBP prevented the mortality in C. albicans bloodstream infection.
由于越来越多的患者经历了由念珠菌属引起的血流感染，并且这种感染的死亡率很高，因此需要制定策略来降低这种情况。一种可能的策略是使用新的药物，如果糖-1,6-二磷酸（FBP），它是一种高能糖酵解代谢物，已在多种病理情况下显示出治疗效果，如缺血、休克、毒性损伤和细菌性败血症。本文的目的是确定 FBP 在实验性白色念珠菌血流感染中的作用。我们使用了分为三组的实验小鼠：假手术（未诱导）、血流感染（通过气管内滴注白色念珠菌诱导）和 FBP（血流感染加 FBP 500mg/kg 腹腔注射）。采集血液以评估全血细胞计数和细胞因子测定（IL-6 和 MCP-1）。研究结果表明，接受 FBP 的组死亡率显著降低。FBP 组的所有细胞因子和血液学指标均与血流感染组相似，除血小板计数外。FBP 显著防止了血小板的减少。总之，我们的结果表明，FBP 可预防白色念珠菌血流感染的死亡率。
