Department of Neurology, Colentina Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Amino Acids. 2013 Jul;45(1):95-112. doi: 10.1007/s00726-012-1252-8. Epub 2012 Feb 26.
Studies of the last 40 years have brought to light an important physiological network, the endocannabinoid system. Endogenous and exogenous cannabinoids mediate their effects through activation of specific cannabinoid receptors. This modulatory homoeostatic system operates in the regulation of brain function and also in the periphery. The cannabinoid system has been shown to be involved in regulating the immune system. Studies examining the effect of cannabinoid-based drugs on immunity have shown that many cellular and cytokine mechanisms are modulated by these agents, thus raising the hypothesis that these compounds may be of value in the management of chronic inflammatory diseases. The special properties of endocannabinoids as neurotransmitters, their pleiotropic effects and the impact on immune function show that the endocannabinoid system represents a revolving plate of neural and immune interactions. In this paper, we outline current information on immune effects of cannabinoids in health and disease.
过去 40 年的研究揭示了一个重要的生理网络——内源性大麻素系统。内源性和外源性大麻素通过激活特定的大麻素受体来发挥作用。这个调节性同型平衡系统在大脑功能和外周组织的调节中发挥作用。大麻素系统已被证明参与调节免疫系统。研究表明，基于大麻素的药物对免疫的影响，这些药物调节许多细胞和细胞因子机制，从而提出了这些化合物可能对慢性炎症性疾病的治疗有价值的假说。内源性大麻素作为神经递质的特殊性质、其多效性作用以及对免疫功能的影响表明，内源性大麻素系统代表了神经和免疫相互作用的一个旋转盘。本文概述了大麻素在健康和疾病中的免疫作用的最新信息。
