Department of Neurology, Colentina Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Immunobiology. 2010 Aug;215(8):588-97. doi: 10.1016/j.imbio.2009.12.005. Epub 2010 Jan 4.
Cannabinoids can influence the immune network. Data on the impact of exogenous cannabinoid ligands on immune function serve not only to understand how the endocannabinoid system modulates immune phenomena associated with infection or inflammation, but also to identify therapeutic targets for immune diseases. Cannabinoids can modulate immune reactions in the periphery but also in the brain, influence T cell subset balance and cytokine expression and play a role in the balance between neuroinflammation and neurodegeneration. Immune cells can synthesize endocannabinoids and also be influenced by cannabinoid analogues. Cannabinoid receptors show different expression on immune cells depending on activation status and stimuli. The complexity of relation between cannabinoid ligands of various classes and cannabinoid receptors brought the need to refine the simple conceptual frame of agonist-antagonists and offered potential implications for understanding interactions in pathological conditions. The immune influence of cannabinoid ligands is not fully elucidated. However, aspects of their immunomodulatory effects provide the basis for a context-dependent targeted therapeutic approach, thus leading to the possibility for the use of cannabinoids in the treatment of inflammatory disease.
大麻素可以影响免疫网络。关于外源性大麻素配体对免疫功能的影响的数据，不仅有助于了解内源性大麻素系统如何调节与感染或炎症相关的免疫现象，还有助于确定免疫疾病的治疗靶点。大麻素可以调节外周和大脑中的免疫反应，影响 T 细胞亚群平衡和细胞因子表达，并在神经炎症和神经退行性变之间的平衡中发挥作用。免疫细胞可以合成内源性大麻素，也可以受到大麻素类似物的影响。大麻素受体在不同的激活状态和刺激下，在免疫细胞上的表达也不同。不同类别大麻素配体与大麻素受体之间关系的复杂性，需要对激动剂-拮抗剂这一简单概念框架进行细化，并为理解病理条件下的相互作用提供了潜在的启示。大麻素配体的免疫影响尚未完全阐明。然而，它们免疫调节作用的各个方面为基于上下文的靶向治疗方法提供了基础，从而为大麻素在治疗炎症性疾病中的应用提供了可能性。
