Corredoira J C, González M, Pérez R, Casariego E, López M J, García J F, Arias J
Servicio de Medicina Interna, Hospital Xeral de Lugo, Santiago.
Rev Clin Esp. 1990 May;186(8):378-82.
The clinical, analytical, evolutive and therapeutic aspects of 33 cases of polycythemia vera which were diagnosed according to the Polycythemia Vera Study Group criteria, are described. Mean age was 65 years with a slight predominance of females (54.5%). Hemorrhagic manifestations were the most frequent (67%) with a great number of patients with digestive manifestations consisting of GI hemorrhage, abdominal pain, portal or suprahepatic veins thrombosis. Splenomegaly was the most frequently found sign upon examination (73%). The mean hemoglobin leukocyte, and platelet levels were 18 g/dl, 16,000 mm3 and 738,000 mm3 respectively. It is note worthy the value of the erythropoietin for the differential diagnosis of secondary erythrocytosis as well as the value of the bone marrow histologic study which should be included in the diagnostic criteria of the disease. The evolution of the process is favorably altered by bleedings and chemotherapeutic cytoreduction which are often performed simultaneously.
描述了33例根据真性红细胞增多症研究组标准诊断的真性红细胞增多症患者的临床、分析、演变及治疗方面的情况。平均年龄为65岁，女性略占优势（54.5%）。出血表现最为常见（67%），大量患者有消化系统表现，包括胃肠道出血、腹痛、门静脉或肝上静脉血栓形成。脾肿大是检查时最常发现的体征（73%）。血红蛋白、白细胞和血小板的平均水平分别为18g/dl、16,000/mm³和738,000/mm³。值得注意的是促红细胞生成素在继发性红细胞增多症鉴别诊断中的价值以及骨髓组织学研究的价值，后者应纳入该疾病的诊断标准。放血和化疗性细胞减少常常同时进行，这对病程的演变有有利影响。
