Lv Yuan, Wang Xiao-Na, Liang Han
Department of Gastric Cancer, Tianjin Cancer Hospital, Tianjin, China.
Zhonghua Wei Chang Wai Ke Za Zhi. 2012 Feb;15(2):157-60.
To study the clinical diagnosis, treatment and prognosis of primary gastric lymphoma (PGL).
Clinical data of 200 patients with PGL who were treated at the Tianjin Cancer Hospital were retrospectively reviewed.
There were 110 males and 90 females. The age ranged between 19 and 80 (median, 54) years old. Symptoms or laboratory examinations were not specific. Before the treatment, 130 cases were diagnosed correctly, and the remaining 70 were misdiagnosed as gastric cancer (n=59), gastric ulcer (n=5) and chronic gastritis (n=6). Twenty-four cases received chemotherapy alone, 29 cases surgery alone, 132 cases underwent surgery plus chemotherapy, and 15 were not treated. The 200 cases all received follow-up ranging from 1 to 246 months (median, 26 months). The 1, 3, 5, and 10-year survival rates were 65.0%, 57.5%, 56.2%, and 55.0%. Univariate analysis and multivariate analysis showed that emaciation (P<0.01), tumor location (P<0.01), treatment modality (P<0.01), histological type (P<0.05), and tumor staging (P<0.05) were independent factors of survival in patients with PGL.
The misdiagnosis of PGL is very frequent. The treatment of choice should be comprehensive therapy based on surgery.
研究原发性胃淋巴瘤（PGL）的临床诊断、治疗及预后。
回顾性分析在天津医科大学肿瘤医院接受治疗的200例PGL患者的临床资料。
男性110例，女性90例。年龄19～80岁（中位年龄54岁）。症状及实验室检查均无特异性。治疗前，130例诊断正确，其余70例误诊为胃癌（59例）、胃溃疡（5例）和慢性胃炎（6例）。24例单纯接受化疗，29例单纯接受手术，132例接受手术加化疗，15例未接受治疗。200例均获随访，随访时间1～246个月（中位随访时间26个月）。1、3、5和10年生存率分别为65.0%、57.5%、56.2%和55.0%。单因素分析和多因素分析显示，消瘦（P<0.01）、肿瘤部位（P<0.01）、治疗方式（P<0.01）、组织学类型（P<0.05）和肿瘤分期（P<0.05）是PGL患者生存的独立影响因素。
PGL误诊率较高。治疗应首选以手术为主的综合治疗。
