Andriani A, Mosiello G, Chiappetta M G, Gregori G, Rinaldi P
Ospedale San Giacomo, USL RM 1, Roma.
Recenti Prog Med. 1990 Jan;81(1):49-53.
A long-term administration of Indobufen, 400 mg daily, was evaluated in 57 patients with cardiovascular diseases. Aggregation waves induced by ADP, collagen and epinephrine showed a significant and persistent inhibition of platelet function. Minor side effects were observed and in 6 patients the drug was withdrawn: 4 patients began to experience gastric troubles, 1 patient had positive occult test for blood, 1 patient developed an allergic rush. Clinical evaluation and platelet aggregation study before starting indobufen and during the follow up period seem to be useful in the evaluation of effectiveness, safety, compliance and suitable daily dose.
对57例心血管疾病患者进行了每日400毫克吲哚布芬的长期给药评估。由二磷酸腺苷（ADP）、胶原和肾上腺素诱导的聚集波显示血小板功能受到显著且持续的抑制。观察到有轻微副作用，6例患者停药：4例患者开始出现胃部不适，1例患者潜血试验呈阳性，1例患者出现过敏疹。开始使用吲哚布芬前及随访期间的临床评估和血小板聚集研究，在评估有效性、安全性、依从性和合适的每日剂量方面似乎很有用。
