Rdzanek H, Kochmański M, Zochowski R J
Oddziału Kardiologii Centralnego Szpitala Klinicznego MSW, Warszawie.
Wiad Lek. 1993 Apr;46(7-8):245-9.
The study included 20 patients aged from 50 to 65 years with stable coronary disease. In all patients exercise ECG test in Quinton moving track was performed before the treatment, and after one, three, and eight weeks of therapy. Besides that, before the treatment, and after each exercise, platelet aggregation, viscosity of whole blood and plasma, and filtration time of 1 ml of whole blood were evaluated. It was found that already after one week of treatment indobufen caused a decrease of platelet aggregation, reduction of viscosity of whole blood and plasma, and improvement of erythrocyte compliance which favourable effects increased with the continuation of the therapy up to eight weeks. At the same time as a result of eight weeks of treatment a significant improvement was achieved of exercise tolerance in the treated patients.
该研究纳入了20例年龄在50至65岁之间的稳定型冠心病患者。所有患者在治疗前以及治疗1周、3周和8周后均进行了Quinton运动平板心电图测试。除此之外，在治疗前以及每次运动后，评估了血小板聚集、全血和血浆粘度以及1毫升全血的过滤时间。结果发现，吲哚布芬治疗1周后即引起血小板聚集减少、全血和血浆粘度降低以及红细胞顺应性改善，随着治疗持续至8周，这些有益作用增强。同时，经过8周治疗，治疗组患者的运动耐量有显著改善。
