Feng Juqiang, Huang Zhixiong, Mu Lihua, Zhao Haixia, Liu Ping
Department of Clinic Pharmacology, General Hospital of PLA, Beijing 100853, China.
Zhongguo Zhong Yao Za Zhi. 2011 Dec;36(24):3463-6.
To study the chemical constituents of the dried rhizome of Ardisia gigantifolia.
The 60% ethanol extract was extracted with EtOAc, and then separated and purified by column chromatography using silica gel and preparative HPLC. Their structures were identified on the basis of spectral analysis and physico-chemical properties.
Nine compounds were isolated and identified as 11-O-galloylbergenin (1), 11-O-syringylbergenin (2), 11-O-protocatechuoylbergenin (3), 4-O-galloylbergenin (4), 11 -O-vanilloylbergenin (5), (-) -epicatechin-3-gallate (6), stigmasterol-3-O-beta-D-glucopyranoside (7), (-) -4'-hydroxy-3-methoxyphenyl-beta-D-[6-O-(4"-hydroxy-3", 5"-dimethoxybenzoyl)] -glucopyranoside (8), and beta-sitosterol (9).
Compounds 3, 4 and 7 were isolsted from the genus Ardisia for the first time, while compounds 1, 2, 5 and 6 were isolated from this plant for the first time.
研究大罗伞干燥根茎的化学成分。
60%乙醇提取物用乙酸乙酯萃取，然后通过硅胶柱色谱和制备型高效液相色谱进行分离纯化。根据光谱分析和理化性质鉴定其结构。
分离鉴定出9个化合物，分别为11 -O-没食子酰bergenin（1）、11 -O-丁香酰bergenin（2）、11 -O-原儿茶酰bergenin（3）、4 -O-没食子酰bergenin（4）、11 -O-香草酰bergenin（5）、（-）-表儿茶素-3-没食子酸酯（6）、豆甾醇-3-O-β-D-葡萄糖苷（7）、（-）-4'-羟基-3-甲氧基苯基-β-D-[6-O-（4"-羟基-3"，5"-二甲氧基苯甲酰基）]-葡萄糖苷（8）和β-谷甾醇（9）。
化合物3、4和7首次从紫金牛属植物中分离得到，化合物1、2、5和6首次从该植物中分离得到。
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