Department of Internal Medicine, Bezmialem Vakif University, Medical Faculty, Fatih, Istanbul, Turkey.
Acta Neurol Belg. 2011 Dec;111(4):282-6.
The prevalence of restless legs syndrome (RLS) is increased in gluten sensitive enteropathy (GSE); but prevalence of GSE is not known in RLS. 96 RLS patients and 97 healthy controls, both with or without iron deficiency were enrolled. All secondary RLS patients except iron deficiency were excluded. Subjects underwent a thorough biochemistry and routine blood analyses, and tissue transglutaminase antibodies (TTGA), endomysium antibodies (EMA) and gliadin antibodies (AGA) were also tested. In RLS patients positivity rates of all GSE antibodies were similar to those in controls. The rate of iron deficiency anaemia in RLS patients with at least one positive GSE antibody was significantly higher than that of RLS patients whose GSE antibodies were all negative. The prevalence of GSE antibodies in RLS patients is not increased. GSE might have a role in the aetiology of RLS in association with iron deficiency anaemia. Since the prevalence of GSE antibodies is not increased in RLS, it seems unlikely that GSE is involved in the aetiology of RLS through different mechanisms (e.g. immunological mechanisms) other than iron deficiency as proposed in some published papers.
不宁腿综合征（RLS）的患病率在麸质敏感肠病（GSE）中增加；但在 RLS 中，GSE 的患病率尚不清楚。共纳入 96 例 RLS 患者和 97 名健康对照者，两组均有或无缺铁。所有继发性 RLS 患者除缺铁外均被排除。所有受试者均接受了全面的生化和常规血液分析，还检测了组织转谷氨酰胺酶抗体（TTGA）、内肌膜抗体（EMA）和麦胶蛋白抗体（AGA）。在 RLS 患者中，所有 GSE 抗体的阳性率与对照组相似。至少有一种 GSE 抗体阳性的 RLS 患者的缺铁性贫血发生率明显高于 GSE 抗体均为阴性的 RLS 患者。RLS 患者的 GSE 抗体患病率并未增加。GSE 可能与缺铁性贫血一起在 RLS 的发病机制中起作用。由于在 RLS 中并未增加 GSE 抗体的患病率，因此似乎不太可能像一些已发表的论文中所提出的那样，GSE 通过不同于缺铁的其他机制（例如免疫机制）参与 RLS 的发病机制。
