Department of Neurology, Medical University Graz, Graz, AT.
St. Elizabeth University of Health and Social Work, Bratislava, SK.
Tremor Other Hyperkinet Mov (N Y). 2020 Aug 25;10:32. doi: 10.5334/tohm.74.
The importance of vitamin D deficiency in Parkinson's disease, its negative influence on bone health, and even disease pathogenesis has been studied intensively. However, despite its possible severe impact on health and quality of life, there is not a sufficient understanding of its role in other movement disorders. This systematic review aims at providing an overview of the prevalence of vitamin D deficiency, bone metabolism alterations, and fractures in each of the most common hyperkinetic movement disorders (HKMDs).
The study search was conducted through PubMed with keywords or Medical Related Subjects (MeSH) of common HKMDs linked with the terms of vitamin D, osteoporosis, injuries, and fractures.
Out of 1585 studies screened 40 were included in our review. They show that there is evidence that several HKMDs, including Huntington disease, Restless Legs Syndrome, and tremor, are associated with low vitamin D serum levels in up to 83% and 89% of patients. Reduced bone mineral density associated with vitamin D insufficiency was described in Huntington disease.
Our survey suggests that vitamin D deficiency, bone structure changes, and fractures are important but yet under-investigated issues in HKMDs. HKMDs-patients, particularly with a history of previous falls, should have their vitamin D-levels tested and supplemented where appropriate.
Contrary to Parkinson's disease, vitamin D deficiency, and bone abnormalities are under-investigated in hyperkinetic movement disorders (HKMDs). Several HKMDs, including essential tremor, RLS, and Huntington disease, are associated with vitamin D deficiency in up to 89%, the latter also with reduced bone mineral density. Testing and where appropriate supplementation is recommended.
维生素 D 缺乏症在帕金森病中的重要性、其对骨骼健康的负面影响，甚至对疾病发病机制的影响，都已经得到了深入研究。然而，尽管它可能对健康和生活质量产生严重影响，但人们对其在其他运动障碍中的作用仍缺乏足够的认识。本系统综述旨在概述每种常见的不自主运动障碍（HKMD）中维生素 D 缺乏症、骨代谢改变和骨折的患病率。
通过 PubMed 进行研究检索，使用常见的 HKMD 的关键词或医学主题词（MeSH）与维生素 D、骨质疏松症、损伤和骨折等术语相关联。
在筛选出的 1585 项研究中，有 40 项研究纳入了我们的综述。这些研究表明，有证据表明，包括亨廷顿病、不宁腿综合征和震颤在内的几种 HKMD，高达 83%和 89%的患者存在低维生素 D 血清水平。亨廷顿病患者存在与维生素 D 不足相关的骨矿物质密度降低。
我们的调查表明，维生素 D 缺乏症、骨骼结构变化和骨折是 HKMD 中重要但研究不足的问题。HKMD 患者，特别是有既往跌倒史的患者，应检测其维生素 D 水平并在适当情况下进行补充。
与帕金森病不同，维生素 D 缺乏症和骨骼异常在不自主运动障碍（HKMD）中研究不足。几种 HKMD，包括特发性震颤、不宁腿综合征和亨廷顿病，与高达 89%的维生素 D 缺乏症相关，后者还与骨矿物质密度降低有关。建议进行检测，并在适当情况下进行补充。
