Institute of Neurosurgery, Catholic University School of Medicine, Rome, Italy.
Acta Neurol Belg. 2011 Dec;111(4):365-70.
Giant frontal mucocele (GFM) is an extremely rare cause of frontal lobe syndrome. Subdural empyema (SDE) is an uncommon complication of paranasal sinisutis, for which craniotomy and decompressive craniotomy are the most effective surgical procedures.
A 54-year-old man was brought unconscious to the Emergency Room where recurrent generalized seizures occurred. Heroine abuse, HCV related hepatitis, prolonged antibiotic therapy for treatment of purulent rhinorrhea, along with recent personality changes, was reported. High white blood cell count, pansinusitis, GFM, SDE and cerebritis were documented. The patient underwent bifrontal craniotomy in emergency, extensive drilling of the inner aspect of the frontal bone, surgical toilette of the enlarged frontal sinus and its "cranialization". Prevotella intermedia and Fusobacterium nucleatum were isolated and antibiotic therapy was started intravenously and then continued orally for three months. Two years later the patient has recovered, though minor signs of frontal lobe syndrome persist.
To the Authors knowledge this is the first case of GFM with SDE reported in the literature. Although decompressive craniectomy is advocated in extreme conditions, as in this case, "internal decompressive craniectomy", obtained with craniotomy and cranialization of the frontal sinuses, is strongly advocated in cases of SDE associated with megasinuses.
巨大额窦黏液囊肿(GFM)是引起额叶综合征的极罕见原因。硬脑膜下积脓(SDE)是鼻窦感染的罕见并发症,开颅术和减压性开颅术是最有效的手术治疗方法。
一名 54 岁男性因意识不清被送往急诊室,期间反复发作全身强直阵挛性发作。有海洛因滥用史、丙型肝炎相关肝炎、治疗脓性鼻漏的抗生素治疗时间延长,以及最近的人格改变。高白细胞计数、全鼻窦炎、GFM、SDE 和脑脓肿均有记录。患者急诊行双额开颅术,广泛钻除额骨内侧面,扩大的额窦及其“颅化”手术清创。分离出中间普雷沃菌和核梭杆菌,并开始静脉内使用抗生素治疗,然后继续口服三个月。两年后,患者已康复,但仍有轻微的额叶综合征迹象。
据作者所知,这是文献中首例报道的 SDE 合并 GFM 病例。尽管在极端情况下提倡减压性开颅术,如本例患者,但在 SDE 合并巨大额窦时,强烈提倡行开颅术和额窦颅化术的“内减压性开颅术”。