Digestive Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Arch Iran Med. 2012 Mar;15(3):166-70.
Chronic inflammation plays a pivotal role in the development of colorectal cancer (CRC) in patients with inflammatory bowel disease (IBD). An orchestrated interplay of immune cells with numerous inflammatory mediators including reactive oxygen and nitrogen species, cyclooxygenase 2, and several cytokines promotes colitis-associated cancer (CAC). Recent findings have shown that inflammatory pathways not only are important in the development of CAC but are also involved in the pathogenesis of sporadic CRC. Hereby, we review the existing experimental and clinical evidence that suggest a link between inflammation and tumorigenesis in sporadic CRC.
慢性炎症在炎症性肠病（IBD）患者的结直肠癌（CRC）发展中起着关键作用。免疫细胞与许多炎症介质（包括活性氧和氮物种、环氧化酶 2 和几种细胞因子）的协调相互作用促进了结肠炎相关癌症（CAC）的发生。最近的研究结果表明，炎症途径不仅在 CAC 的发展中很重要，而且还参与了散发性 CRC 的发病机制。在此，我们综述了现有的实验和临床证据，这些证据表明炎症与散发性 CRC 的肿瘤发生之间存在联系。
