Lulich Jody P, Osborne Carl A, Carvalho Mauricio, Nakagawa Yasushi
Minnesota Urolith Center, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN 55108, USA.
Am J Vet Res. 2012 Mar;73(3):447-51. doi: 10.2460/ajvr.73.3.447.
To evaluate urine concentrations of glycosaminoglycans, Tamm-Horsfall glycoprotein, and nephrocalcin in cats fed a diet formulated to prevent calcium oxalate uroliths.
10 cats with calcium oxalate urolithiasis.
In a previous study conducted in accordance with a balanced crossover design, cats were sequentially fed 2 diets (the diet each cat was consuming prior to urolith detection and a diet formulated to prevent calcium oxalate uroliths). Each diet was fed for 8 weeks. At the end of each 8-week period, a 72-hour urine sample was collected. Concentrations of glycosaminoglycans, Tamm-Horsfall glycoprotein, and the 4 isoforms of nephrocalcin in urine samples collected during that previous study were measured in the study reported here. RESULTS; Diet had no effect on the quantity of Tamm-Horsfall glycoprotein and nephrocalcin in urine. However, the urine concentration of glycosaminoglycans was significantly higher during consumption of the urolith prevention diet.
Feeding a urolith prevention diet increased the urine concentration of glycosaminoglycans, which are glycoprotein inhibitors of growth and aggregation of calcium oxalate crystals.
评估喂食一种旨在预防草酸钙尿石症的日粮的猫尿液中糖胺聚糖、Tamm-Horsfall糖蛋白和肾钙素的浓度。
10只患有草酸钙尿石症的猫。
在之前一项按照平衡交叉设计进行的研究中，猫依次喂食2种日粮（每只猫在尿石检测前食用的日粮和一种旨在预防草酸钙尿石症的日粮）。每种日粮喂食8周。在每个8周周期结束时，收集一份72小时的尿液样本。在此报告的研究中测量了在之前研究期间收集的尿液样本中糖胺聚糖、Tamm-Horsfall糖蛋白和肾钙素4种同工型的浓度。结果：日粮对尿液中Tamm-Horsfall糖蛋白和肾钙素的量没有影响。然而，在食用预防尿石症日粮期间，尿液中糖胺聚糖的浓度显著更高。
喂食预防尿石症的日粮会增加尿液中糖胺聚糖的浓度，糖胺聚糖是草酸钙晶体生长和聚集的糖蛋白抑制剂。
