Blichfeldt Louise, Garvey Lene Heise, Krøigaard Mogens, Mosbech Holger
Anæstesiologisk Afdeling, Sydvestjysk Sygehus Esbjerg, 6700 Esbjerg, Denmark.
Ugeskr Laeger. 2012 Feb 27;174(9):579-80.
Allergic reactions during anaesthesia are rare and the cause is seldom immediately obvious. Incorrect guesses for the offending substance can lead to suboptimal management. Furthermore there is a risk of a serious reaction on subsequent exposure to the real allergen. We present a case of suspected allergy to fentanyl investigated at the Danish Anaesthesia Allergy Centre. Allergy to this drug could not be demonstrated by skin tests or challenge. The reaction was due to unspecific histamine release induced by several opioids given at the same time. Future pretreatment with antihistamine was recommended.
麻醉期间的过敏反应很少见，原因通常不会立即显现。对致敏物质的错误猜测可能导致管理欠佳。此外，后续再次接触真正的过敏原时存在发生严重反应的风险。我们报告一例在丹麦麻醉过敏中心调查的疑似对芬太尼过敏的病例。皮肤试验或激发试验均未证实对该药物过敏。该反应是由于同时给予的几种阿片类药物诱导的非特异性组胺释放所致。建议未来使用抗组胺药进行预处理。
