Laboratory of Oral Infection and Immunology, Institute of Stomatology, Nanjing Medical University, Nanjing, Jiangsu, China.
Arch Oral Biol. 2012 Jun;57(6):585-93. doi: 10.1016/j.archoralbio.2012.01.016. Epub 2012 Feb 25.
The results of recent published studies focusing on interleukin-1 receptor antagonist (IL-1RN) gene variable number of tandem repeats (VNTR) polymorphism in periodontitis susceptibility are often conflicting. We performed a meta-analysis in order to investigate the potential association of IL-1RN VNTR polymorphism with susceptibility to either chronic (CP) or aggressive (AgP) periodontitis.
Nineteen studies involving a total of 2011 cases and 1719 controls were searched without any language restriction. Odds ratios (ORs) along with their 95% confidence intervals (CIs) were calculated to compare the distribution of alleles and genotypes between cases and controls. Both fixed and random effects models were used to pool the data.
The IL-1RN VNTR polymorphism was marginally associated with an elevated risk of CP in overall populations (22 versus LL (L means the long alleles): OR=1.47, 95% CI 1.00-2.18, p=0.05), and the association was consistently significant in severe CP subgroup (OR=4.02, 95% CI 1.84-8.80, p<0.0005). Further stratified analysis restricted to Hardy-Weinberg equilibrium studies showed evidence for an increased risk with CP in Asians (2 allele versus L allele: OR=1.82, 95% CI 1.31-2.54, p<0.0005), however, a decreased risk with AgP in Caucasians (L2 versus LL: OR=0.50, 95% CI 0.32-0.78, p=0.002).
This meta-analysis suggested that IL-1RN VNTR polymorphism might contribute to an increased risk on CP and a decreased risk on AgP. However, further well-designed studies with large sample size are needed to determine the robustness of these observations in different populations.
最近发表的一些研究聚焦于白细胞介素-1 受体拮抗剂（IL-1RN）基因可变数目串联重复（VNTR）多态性与牙周炎易感性的关系，但结果往往存在矛盾。我们进行了一项荟萃分析，旨在研究 IL-1RN VNTR 多态性与慢性（CP）或侵袭性（AgP）牙周炎易感性的潜在关联。
无语言限制地检索了 19 项研究，共纳入 2011 例病例和 1719 例对照。计算比值比（OR）及其 95%置信区间（CI），以比较病例组和对照组等位基因和基因型的分布。采用固定效应模型和随机效应模型合并数据。
IL-1RN VNTR 多态性与总体人群 CP 发病风险增加呈边缘相关（22 与 LL（L 表示长等位基因）：OR=1.47，95%CI 1.00-2.18，p=0.05），且在重度 CP 亚组中相关性一致显著（OR=4.02，95%CI 1.84-8.80，p<0.0005）。进一步对 Hardy-Weinberg 平衡研究进行分层分析显示，亚洲人群 CP 发病风险增加（2 等位基因与 L 等位基因：OR=1.82，95%CI 1.31-2.54，p<0.0005），而白种人群 AgP 发病风险降低（L2 与 LL：OR=0.50，95%CI 0.32-0.78，p=0.002）。
本荟萃分析提示 IL-1RN VNTR 多态性可能导致 CP 发病风险增加，AgP 发病风险降低。然而，需要进一步设计良好、样本量大的研究来确定这些观察结果在不同人群中的稳健性。
