白细胞介素1受体拮抗剂基因86-bp可变数目串联重复序列多态性与脓毒症的关联：一项荟萃分析。

Association between interleukin 1 receptor antagonist gene 86-bp VNTR polymorphism and sepsis: a meta-analysis.

作者信息

Fang Fang, Pan Jian, Li Yiping, Xu Lixiao, Su Guanghao, Li Gang, Wang Jian

机构信息

Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou 215003, China.

出版信息

Hum Immunol. 2015 Jan;76(1):1-5. doi: 10.1016/j.humimm.2014.12.013. Epub 2014 Dec 11.

DOI:10.1016/j.humimm.2014.12.013

PMID:25500257

Abstract

OBJECTIVE

Many studies have focused on the relationship between interleukin 1 receptor antagonist (IL1RN) gene 86-bp VNTR polymorphism and sepsis, but the results remain inconsistent. Thus, a meta-analysis was carried out to derive a more precise estimation of the association between IL1RN 86-bp VNTR polymorphism and risk of sepsis and sepsis-related mortality.

METHODS

Relevant publications were searched in several widely used databases and six eligible studies were included in the meta-analysis. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the association between IL1RN 86-bp VNTR polymorphism and risk of sepsis and sepsis-related mortality.

RESULTS

Significant associations between IL1RN 86-bp VNTR polymorphism and sepsis risk were observed in both overall meta-analysis for L2 versus 22 (OR=0.75, 95% CI=0.59-0.94) and severe sepsis subgroup for LL+L2 versus 22 (OR=0.67, 95% CI=0.47-0.93). L stands for long alleles containing three to six repeats; 2 stands for short allele containing two repeats. However, no significant sepsis mortality variation was detected for all genetic models.

CONCLUSIONS

According to the results of our meta-analysis, the IL1RN 86-bp VNTR polymorphism probably associates with sepsis risk but not with sepsis-related mortality.

摘要

目的

许多研究聚焦于白细胞介素1受体拮抗剂（IL1RN）基因86-bp可变数目串联重复序列（VNTR）多态性与脓毒症之间的关系，但结果仍不一致。因此，进行了一项荟萃分析，以更精确地评估IL1RN 86-bp VNTR多态性与脓毒症风险及脓毒症相关死亡率之间的关联。

方法

在几个广泛使用的数据库中检索相关出版物，六项符合条件的研究纳入荟萃分析。计算合并比值比（OR）和95%置信区间（CI），以评估IL1RN 86-bp VNTR多态性与脓毒症风险及脓毒症相关死亡率之间关联的强度。

结果

在L2与22的总体荟萃分析（OR=0.75，95%CI=0.59-0.94）以及LL+L2与22的严重脓毒症亚组分析（OR=0.67，95%CI=0.47-0.93）中，均观察到IL1RN 86-bp VNTR多态性与脓毒症风险之间存在显著关联。L代表含有三至六个重复序列的长等位基因；2代表含有两个重复序列的短等位基因。然而，在所有遗传模型中均未检测到脓毒症死亡率的显著差异。