Kasamaki Yuji, Izumi Yoichi, Ozawa Yukio, Ohta Masakatsu, Tano Ayako, Watanabe Ichiro, Hirayama Atsushi, Nakayama Tomohiro, Kawamura Hiroshi, Himit Dilxat, Mahemuti Maisumu, Sezai Akira
Division of Cardiology, Department of Medicine, Nihon University School of Medicine, 30-1 Ooyaguchi Kamimachi, Itabashiku, Tokyo, 173-8610, Japan.
Heart Vessels. 2013 Mar;28(2):208-14. doi: 10.1007/s00380-012-0237-6. Epub 2012 Feb 28.
A relationship may exist between plasma atrial natriuretic peptide (P-ANP) and heart rate variability (HRV), which reflects the activity of the autonomic nervous system. We performed a survey in human subjects to examine the relationship between P-ANP and HRV parameters. Three ethnic groups (Han, Uygur, and Kazakh) provided blood and urine samples and underwent 24-h ambulatory blood pressure monitoring and 24-h ECG recording (24-h Holter ECG). There was a positive correlation between P-ANP and HF, as well as a negative correlation between P-ANP and the LF/HF ratio, in all subjects from the 3 ethnic groups. There was no association of BP with any of the blood, urinary, and HRV parameters. Our results suggested the possibility of a relationship between P-ANP and HRV, which reflects autonomic activity. These findings are consistent with the previous report of a close relationship between ANP and cardiac parasympathetic and/or sympathetic activity.
血浆心钠素（P-ANP）与心率变异性（HRV）之间可能存在某种关系，HRV反映了自主神经系统的活动。我们对人类受试者进行了一项调查，以研究P-ANP与HRV参数之间的关系。三个民族（汉族、维吾尔族和哈萨克族）提供了血液和尿液样本，并接受了24小时动态血压监测和24小时心电图记录（24小时动态心电图）。在这三个民族的所有受试者中，P-ANP与高频功率（HF）呈正相关，与低频功率/高频功率比值（LF/HF）呈负相关。血压与任何血液、尿液和HRV参数均无关联。我们的结果提示P-ANP与反映自主神经活动的HRV之间可能存在某种关系。这些发现与之前关于心钠素与心脏副交感和/或交感神经活动密切关系的报道一致。
