Department of Obstetrics and Gynecology, University of Florida, Gainesville, FL 32610-0294, USA.
J Low Genit Tract Dis. 2012 Apr;16(2):149-54. doi: 10.1097/LGT.0b013e318231217b.
Angiomyofibroblastoma (AMF) is a benign mesenchymal tumor usually found in the vulva. We reviewed 70 cases of vulvar AMF that have been reported in the English-language literature and report 1 case of a pedunculated variant. Our case brings the total reported to 71 and is only the fourth pedunculated variant reported.
This 50-year-old woman presented to our gynecology clinic with a 1-year history of a left labial mass. It began as pea-sized, and rapidly grew to 12 cm in diameter. Physical examination demonstrated a 12-cm pedunculated soft mass arising from the left labia majora. The clinical diagnosis was aggressive angiomyxoma, and a simple excision was performed. The final pathology demonstrated AMF. The patient remains free from tumor at 4 years of follow-up.
Seventy-one cases were summarized. The mean age at presentation was 45 years. The lesions were equally distributed between the left (52%) and right (48%). The most common clinical diagnosis was a Bartholin gland cyst (46%) or lipoma (15%). The mean duration of the lesion before seeking treatment was 29 months, and the mean diameter at presentation was 5.9 cm. All of the patients were treated with simple excision. The mean duration of follow-up was 37 months. There was 1 report of sarcomatous transformation 2 years after initial treatment.
Angiomyofibroblastoma is a rare benign tumor that most often occurs in the vulva. Differential diagnosis may include aggressive angiomyxoma, Bartholin cyst, or lipoma. The treatment of choice is simple total excision, which is usually curative.
血管肌纤维母细胞瘤（AMF）是一种常见于外阴的良性间叶肿瘤。我们复习了英文文献中报道的 70 例外阴 AMF 病例，并报告了 1 例带蒂变异型。我们的病例使报告总数达到 71 例，并且是第四例带蒂变异型。
这位 50 岁女性因左阴唇肿块 1 年就诊于妇科诊所。它起初像豌豆大小，迅速长到 12 厘米直径。体格检查显示一个 12 厘米的带蒂软组织肿块从左大阴唇长出。临床诊断为侵袭性血管黏液瘤，行单纯切除术。最终病理显示为 AMF。患者在 4 年的随访中无肿瘤复发。
总结了 71 例病例。发病时的平均年龄为 45 岁。病变在左侧（52%）和右侧（48%）分布均匀。最常见的临床诊断为巴氏腺囊肿（46%）或脂肪瘤（15%）。就诊前病变的平均持续时间为 29 个月，就诊时的平均直径为 5.9 厘米。所有患者均接受单纯切除术治疗。平均随访时间为 37 个月。有 1 例报告在初次治疗后 2 年发生肉瘤样变。
血管肌纤维母细胞瘤是一种罕见的良性肿瘤，最常发生在外阴。鉴别诊断可能包括侵袭性血管黏液瘤、巴氏腺囊肿或脂肪瘤。治疗选择是单纯完全切除，通常可治愈。
