ENT Department, Päijät-Häme Central Hospital, Lahti, Finland.
Otolaryngol Head Neck Surg. 2012 Jul;147(1):119-26. doi: 10.1177/0194599812438168. Epub 2012 Feb 27.
To show that mastoid cavities with continuous infections and cleaning problems can be obliterated with bioactive glass (BG) and to present results of a pilot study for 16 operations on adults.
Case series with planned data collection.
Päijät-Häme Central Hospital, Finland-a single ear, nose, and throat (ENT) hospital department serving a population of 216,000.
Fourteen patients had a large open radical cavity with recurrent infections. Two ears had discharge and pain after simple mastoidectomy. A re-mastoidectomy included support of the cavity skin and obliteration with BG. The mean follow-up time was 2.2 years.
All ears became dry. One reoperation was needed as the fascia support to the ear canal (EC) skin was too weak, and part of the BG leaked into the EC. The ear stayed dry, and the missing BG was replaced in a reoperation. A slightly short musculoperiosteal flap supported the EC skin in 1 ear. A minor amount of BG leaked into the EC. The ear stayed dry. The aim was an ample ear canal. One ear was overfilled and required meatoplasty. Simple mastoid cavities were isolated from the middle ear and become asymptomatic.
In this pilot study, BG works safely and with success as an obliteration material in problematic open radical cavities. Bioactive glass seems to tolerate chronic infection in the mastoid and prevent postoperative infections.
展示生物活性玻璃（BG）可用于封闭持续感染和清洁问题严重的乳突腔，并介绍针对 16 例成人手术的初步研究结果。
有计划数据收集的病例系列。
芬兰派亚特-哈梅中央医院，这是一家专门从事耳鼻喉科（ENT）的医院，服务于 21.6 万人口。
14 例患者存在大的开放式根治性乳突腔，伴有反复感染。2 例患者在单纯乳突切除术后出现溢液和疼痛。再行乳突切除术，包括耳腔皮肤的支撑和 BG 封闭。平均随访时间为 2.2 年。
所有耳朵均干燥。1 例因耳腔皮肤筋膜支撑力不足，部分 BG 漏入耳腔，需再次手术。耳朵保持干燥，且在再次手术中更换了缺失的 BG。1 例因肌骨膜瓣略短，支撑耳腔皮肤，少量 BG 漏入耳腔，耳朵保持干燥。手术目的是形成宽敞的耳道。1 例耳朵填充过度，需行耳成形术。单纯乳突腔与中耳隔离，无症状。
在这项初步研究中，BG 作为一种封闭材料，在有问题的开放式根治性乳突腔中安全有效。生物活性玻璃似乎能耐受乳突内的慢性感染，并预防术后感染。
