乳突切除术后生物活性玻璃S53P4诱导骨形成的18F-NaF PET/CT成像
18F-NaF PET/CT imaging of bone formation induced by bioactive glass S53P4 after mastoid obliteration.
作者信息
Timmermans Adriana J, Quak Jasper J, Hagen Petronella J, Colnot David R
机构信息
Department of Otorhinolaryngology and Head and Neck Surgery, Diakonessenhuis, Bosboomstraat 1, 3582 KE, Utrecht, The Netherlands.
Department of Nuclear Medicine, Diakonessenhuis, Utrecht, The Netherlands.
出版信息
Eur J Hybrid Imaging. 2019 Oct 31;3(1):18. doi: 10.1186/s41824-019-0065-3.
PURPOSE
Bioactive glass has been successfully used for surgical treatment of chronic infections in bone and bone cavities. Besides infection control, new bone formation is induced by the bioactive glass which is considered to have osteoconductive properties. Evaluation of postsurgical changes after bone graft surgery is generally performed with conventional radiographs or CT/MR imaging, but 18F-NaF PET/CT might be more suitable since it has a high and rapid bone uptake, accompanied by a fast blood clearance leading to a high bone to background ratio.
CASE
Obliteration with S53P4 bioactive glass of the mastoid and middle ear was performed in a patient suffering from chronic otitis media. Control of the chronic otitis media was achieved, and follow-up imaging after 3 years with 18F-NaF PET/CT showed increased uptake in the obliterated cavity indicating new bone formation.
CONCLUSION
18F-NaF PET/CT is able to detect new bone formation after obliteration of the mastoid with S53P4 bioactive glass.
目的
生物活性玻璃已成功用于骨和骨腔慢性感染的外科治疗。除了控制感染外，生物活性玻璃还能诱导新骨形成，被认为具有骨传导特性。骨移植手术后的术后变化评估通常采用传统X线片或CT/MR成像，但18F-NaF PET/CT可能更合适，因为它对骨的摄取高且迅速，同时血液清除快，导致骨与本底比值高。
病例
对一名慢性中耳炎患者进行了用S53P4生物活性玻璃填充乳突和中耳的手术。慢性中耳炎得到了控制，3年后用18F-NaF PET/CT进行的随访成像显示，填充腔内的摄取增加，表明有新骨形成。
结论
18F-NaF PET/CT能够检测出用S53P4生物活性玻璃填充乳突后新骨的形成。
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