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饮酒与高血压男性血脂谱的关系。

Association of alcohol consumption with lipid profile in hypertensive men.

机构信息

Department of Epidemiology and Health Promotion, Kyungpook National University, Daegu, Republic of Korea.

出版信息

Alcohol Alcohol. 2012 May-Jun;47(3):282-7. doi: 10.1093/alcalc/ags019. Epub 2012 Feb 26.

Abstract

AIMS

Alcohol consumption is known to be closely related with alterations in blood lipid levels as well as in blood pressure. The objective of this study was to evaluate the association between alcohol consumption and blood lipid levels in hypertensive men.

METHODS

A cross-sectional study involving participants (n = 2014) aged 20-69 years from the Korea National Health and Nutrition Examination Survey, 1998-2009. Demographic characteristics, dietary intake and medical history were obtained from the participants by questionnaire, and lipid levels were determined by analysis of blood samples.

RESULTS

After adjusting for demographic and dietary factors, alcohol consumption was negatively associated with risk of low high-density lipoprotein cholesterol [HDL-C; odds ratio (OR): 0.29, 95% confidence interval (CI): 0.22-0.40 in heavy (≥30 g/day) drinkers; P for trend <0.001], whereas the risk of high triglycerides increased with increasing alcohol consumption (OR: 2.04, 95% CI: 1.53-2.72 in heavy drinkers; P for trend <0.001). However, the OR of high non-HDL-C and the ratio of high triglycerides to HDL-C did not change significantly with an increase in alcohol consumption.

CONCLUSION

These data suggest that alcohol consumption differentially affected lipid measures according to the amount of alcohol intake in hypertensive men.

摘要

目的

已知饮酒与血脂水平以及血压的变化密切相关。本研究旨在评估饮酒与高血压男性血脂水平之间的关系。

方法

这是一项涉及 1998 年至 2009 年韩国国家健康和营养检查调查中 20-69 岁参与者(n=2014)的横断面研究。通过问卷获得参与者的人口统计学特征、饮食摄入和病史,通过血液样本分析确定血脂水平。

结果

在调整人口统计学和饮食因素后,饮酒与低高密度脂蛋白胆固醇(HDL-C)的风险呈负相关[比值比(OR):重度(≥30g/天)饮酒者为 0.29,95%置信区间(CI):0.22-0.40;P<0.001],而随着饮酒量的增加,甘油三酯升高的风险也随之增加(OR:重度饮酒者为 2.04,95%CI:1.53-2.72;P<0.001)。然而,随着饮酒量的增加,非高密度脂蛋白胆固醇的 OR 和甘油三酯与高密度脂蛋白胆固醇的比值并没有显著变化。

结论

这些数据表明,饮酒对高血压男性的血脂指标的影响因饮酒量的不同而有所不同。

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