CD86 在小鼠造血干细胞上表达，并表示淋系造血潜能。
CD86 is expressed on murine hematopoietic stem cells and denotes lymphopoietic potential.
机构信息
Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
出版信息
Blood. 2012 May 24;119(21):4889-97. doi: 10.1182/blood-2011-10-388736. Epub 2012 Feb 27.
Abstract
A unique subset of CD86(-) HSCs was previously discovered in mice that were old or chronically stimulated with lipopolysaccharide. Functionally defective HSCs were also present in those animals, and we now show that CD86(-) CD150(+) CD48(-) HSCs from normal adult mice are particularly poor at restoring the adaptive immune system. Levels of the marker are high on all progenitors with lymphopoietic potential, and progressive loss helps to establish relations between progenitors corresponding to myeloid and erythroid lineages. CD86 represents an important tool for subdividing HSCs in several circumstances, identifying those unlikely to generate a full spectrum of hematopoietic cells.
摘要
先前在老年或长期受到脂多糖刺激的小鼠中发现了一组独特的 CD86(-) HSCs。这些动物中也存在功能缺陷的 HSCs，我们现在表明，来自正常成年小鼠的 CD86(-) CD150(+) CD48(-) HSCs 特别难以恢复适应性免疫系统。该标志物在所有具有淋巴生成潜力的祖细胞上水平都很高，而进行性丧失有助于建立对应于髓系和红系谱系的祖细胞之间的关系。CD86 是在几种情况下对 HSCs 进行细分的重要工具，可以识别那些不太可能产生全谱造血细胞的 HSCs。
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