伊朗多发性硬化症患者血清铜高锌低：一项病例对照研究。
High copper and low zinc serum levels in Iranian patients with multiple sclerosis: a case control study.
作者信息
Ghazavi Ali, Kianbakht Saeed, Ghasami Keyvan, Mosayebi Ghasem
机构信息
Tuberculosis and Pediatric Infectious Research Center (TPIRC), Department of Immunology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
出版信息
Clin Lab. 2012;58(1-2):161-4.
BACKGROUND
The purpose of this study was to evaluate the levels of zinc (Zn) and copper (Cu) in the serum of Iranian patients with multiple sclerosis (MS).
METHODS
The serum levels of zinc (Zn) and copper (Cu) were measured in sixty Iranian patients with MS and compared with sixty age-, gender- and socioeconomic status-matched healthy subjects without any neurological disorders as controls from the same geographical area.
RESULTS
Significantly lower serum Zn and higher serum Cu levels were found in the MS patients compared with the controls (p < 0.0001 and p = 0.002, respectively). The serum Zn level of the secondary-progressive MS patients was significantly lower compared with the relapsing-remitting MS patients (p = 0.009). There was no significant difference between the serum Cu levels of the two subgroup of MS patients (p = 0.42).
CONCLUSIONS
The results suggest significant deviations of the Iranian MS patients' serum Zn and Cu levels from the norm.
背景
本研究旨在评估伊朗多发性硬化症（MS）患者血清中锌（Zn）和铜（Cu）的水平。
方法
测量了60例伊朗MS患者血清中锌（Zn）和铜（Cu）的水平，并与60例年龄、性别和社会经济状况相匹配、来自同一地理区域且无任何神经系统疾病的健康受试者作为对照进行比较。
结果
与对照组相比，MS患者血清Zn水平显著降低，血清Cu水平显著升高（分别为p < 0.0001和p = 0.002）。继发进展型MS患者的血清Zn水平显著低于复发缓解型MS患者（p = 0.009）。MS患者两个亚组的血清Cu水平之间无显著差异（p = 0.42）。
结论
结果表明伊朗MS患者血清Zn和Cu水平与正常水平存在显著偏差。
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