Cardiovascular Department, Mazandaran Heart Center, Mazandaran University of Medical Sciences, Artesh BLVD, Sari, Mazandaran, Iran.
Biol Trace Elem Res. 2011 Dec;143(3):1239-46. doi: 10.1007/s12011-011-8956-6. Epub 2011 Jan 22.
Oxidative stress is involved in the pathogenesis of congestive heart failure (CHF). Some trace elements serve as antioxidant defenses. The purpose of this study was to analyze the effect of atrial fibrillation (AF) on zinc (Zn) and copper (Cu) levels in patients with advanced CHF. In this prospective study, serum Zn and Cu levels in 78 patients with clinically advanced CHF, i.e., New York Heart Association (NYHA) functional class III or IV (40 patients with AF and 38 in sinus rhythm) were measured using atomic absorption spectrophotometry. All patients also had a left ventricular ejection fraction (EF) of <35%. We recruited 40 volunteers with nearly the same age and weight as control. They had normal EF. There was no significant difference between patients with AF and those with sinus rhythm regarding serum Zn and Cu levels. However, both groups showed significant hypozincemia (p < 0.000) and a decreased Zn/Cu ratio (p < 0.03) compared with control group. Serum Cu levels were similar in the two groups and did not differ significantly from the control group. In patients with advanced CHF, irrespective of the rhythm, profound hypozincemia, and a decreased Zn/Cu ratio were present, which could be secondary to the activation of the renin-angiotensin-aldosterone system and CHF medications. The results suggest the need for more studies focusing on possible benefits with Zn nutriceutical replacement in patients with advanced CHF.
氧化应激与充血性心力衰竭（CHF）的发病机制有关。一些微量元素作为抗氧化防御。本研究旨在分析心房颤动（AF）对晚期 CHF 患者锌（Zn）和铜（Cu）水平的影响。在这项前瞻性研究中，使用原子吸收分光光度法测量了 78 例临床晚期 CHF 患者（纽约心脏协会[NYHA]功能 III 或 IV 级，40 例 AF 和 38 例窦性节律）的血清 Zn 和 Cu 水平。所有患者的左心室射血分数（EF）均<35%。我们招募了 40 名年龄和体重与对照组几乎相同的志愿者。他们的 EF 正常。AF 患者与窦性节律患者的血清 Zn 和 Cu 水平无显着差异。然而，与对照组相比，两组均表现出明显的低锌血症（p<0.000）和 Zn/Cu 比值降低（p<0.03）。两组的血清 Cu 水平相似，与对照组无显着差异。在晚期 CHF 患者中，无论节律如何，均存在严重的低锌血症和 Zn/Cu 比值降低，这可能继发于肾素-血管紧张素-醛固酮系统和 CHF 药物的激活。结果表明需要进行更多研究，重点关注晚期 CHF 患者使用 Zn 营养补充剂可能带来的益处。
