Department of Pathology, HUSLAB and Helsinki University Hospital, Finland.
Arch Pathol Lab Med. 2012 Mar;136(3):241-52. doi: 10.5858/arpa.2010-0216-RA.
Diagnosing epithelioid serosal lesions remains a challenge because numerous different processes-primary or secondary, benign or malignant-occur in body cavities, some of which are very rare.
To review the newest literature and to describe the morphologic criteria and immunohistochemical markers that are useful for distinguishing epithelioid serosal lesions.
Previously published literature concentrating on the newest research findings. Earlier reviews are principally referred to for established diagnostic criteria.
Immunohistochemistry with a panel of antibodies has made the diagnosis of epithelioid serosal lesions very reliable. When deciding on antibodies used in differential diagnosis, it is important to consider tumor location, clinical and radiologic information, and morphologic features. Immunohistochemistry is less useful in the differential diagnosis of benign versus malignant mesothelial lesions. The diagnosis of benign versus malignant mesothelial proliferations still relies on the histologic criteria of invasion.
诊断上皮样浆膜病变仍然具有挑战性，因为许多不同的过程——原发性或继发性、良性或恶性——发生在体腔中，其中一些非常罕见。
回顾最新文献，描述用于区分上皮样浆膜病变的形态学标准和免疫组织化学标志物。
以前发表的文献集中于最新的研究发现。更早的综述主要是为了建立诊断标准而引用的。
用一组抗体进行免疫组织化学检查使上皮样浆膜病变的诊断非常可靠。在决定用于鉴别诊断的抗体时，重要的是要考虑肿瘤的位置、临床和影像学信息以及形态学特征。免疫组织化学在鉴别良性与恶性间皮病变方面的作用较小。良性与恶性间皮增生的诊断仍依赖于侵袭的组织学标准。
