Department of Histopathology, University Hospital Llandough, Cardiff, United Kingdom.
Arch Pathol Lab Med. 2012 Mar;136(3):268-76. doi: 10.5858/arpa.2011-0150-SA.
A diverse and complex variety of lymphoproliferative diseases may involve the serosa, with widely differing clinical outcomes encompassing a spectrum of benign and malignant conditions.
To review lymphoproliferative disease involving the serosa and to provide a practical approach to the evaluation of lymphoid and plasma cell infiltrates in the serosa, together with a review of various tumors and tumorlike conditions that may mimic lymphoproliferative disease.
Analysis of published literature.
All forms of hematologic malignancy may involve the various serosal sites, although this is usually observed as secondary involvement in persons with known lymph nodal, marrow-based, or extranodal disease. Primary pericardial, pleural, and peritoneal lymphomas are rare; many nonneoplastic conditions may mimic lymphoma and a variety of nonhematolymphoid tumors may simulate hematologic malignancies. An understanding of the role of ancillary tests, together with an appreciation of their limitations, will prevent misdiagnosis.
各种不同且复杂的淋巴增生性疾病可能累及浆膜，其临床表现差异很大，涵盖了一系列良性和恶性疾病。
回顾累及浆膜的淋巴增生性疾病，并提供一种实用的方法来评估浆膜中淋巴细胞和浆细胞浸润，同时回顾可能模拟淋巴增生性疾病的各种肿瘤和肿瘤样疾病。
对已发表文献的分析。
所有形式的血液恶性肿瘤都可能累及各种浆膜部位，但通常在已知淋巴结、骨髓或结外部位疾病的患者中观察到继发累及。原发性心包、胸膜和腹膜淋巴瘤罕见；许多非肿瘤性疾病可能类似于淋巴瘤，各种非血液淋巴样肿瘤可能模拟血液恶性肿瘤。了解辅助检查的作用及其局限性将有助于避免误诊。
