锯齿叶金粟兰中的萜类化合物及其抗炎活性。

Terpenoids from Chloranthus serratus and their anti-inflammatory activities.

机构信息

State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.

出版信息

J Nat Prod. 2012 Apr 27;75(4):694-8. doi: 10.1021/np200968p. Epub 2012 Feb 28.

DOI:10.1021/np200968p

PMID:22372956

Abstract

Seven new terpenoids, including two sesquiterpene dimers (1, 2), two norditerpenoids (3, 4), and three sesquiterpenes (5-7), along with six known sesquiterpene dimers and four known sesquiterpenes were isolated from the whole plant of Chloranthus serratus. Their structures and relative configurations were elucidated on the basis of spectroscopic data analysis. The absolute configuration of 1 was determined by the CD exciton chirality method. These isolates were evaluated for their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW264.7 cells. Compound 2 and two known compounds, shizukaols B and D, showed significant anti-inflammatory activities, with IC(50) values of 0.22, 0.15, and 7.22 μM, respectively.

摘要

从全株金粟兰中分离得到 7 个新的萜类化合物，包括 2 个倍半萜二聚体（1、2）、2 个新的降二萜（3、4）和 3 个倍半萜（5-7），以及 6 个已知的倍半萜二聚体和 4 个已知的倍半萜。根据光谱数据分析阐明了它们的结构和相对构型。通过 CD 激子手性法确定了 1 的绝对构型。对这些分离物进行了评价，以评估它们对 RAW264.7 细胞中脂多糖诱导的一氧化氮产生的抑制作用。化合物 2 和两个已知化合物，shizukaols B 和 D，表现出显著的抗炎活性，IC（50）值分别为 0.22、0.15 和 7.22 μM。