通过自激活实现的核酸酶活性和单核铜（II）配合物的抗癌活性：配体框架中叔丁基的新作用。
Nuclease activity via self-activation and anticancer activity of a mononuclear copper(II) complex: novel role of the tertiary butyl group in the ligand frame.
机构信息
Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247667, India.
出版信息
Inorg Chem. 2012 Mar 19;51(6):3343-5. doi: 10.1021/ic2016676. Epub 2012 Feb 28.
Abstract
The copper complex [Cu((t)BuPhimp)(Cl)] (1) derived from tridentate ligand (t)BuPhimpH having N(2)O donors was synthesized, and its molecular structure was determined. A phenoxyl radical complex was generated in solution at room temperature using Ce(IV). The nuclease and anticancer activities of 1 were investigated. The roles of the tert-butyl group and singlet oxygen in the DNA cleavage activity were also discussed.
摘要
铜配合物[Cu((t)BuPhimp)(Cl)]（1）由具有 N(2)O 供体的三齿配体(t)BuPhimpH 衍生而来，其分子结构已确定。室温下使用 Ce(IV)在溶液中生成了一个苯氧自由基配合物。研究了 1 的核酸酶和抗癌活性。还讨论了叔丁基和单线态氧在 DNA 断裂活性中的作用。
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