Department of Chemistry, Indian Institute of Technology, Roorkee, Roorkee-247667, Uttarakhand, India.
Eur J Med Chem. 2010 Sep;45(9):3770-9. doi: 10.1016/j.ejmech.2010.05.026. Epub 2010 May 19.
Tridentate ligand PhimpH binds to Cu(II) centre after deprotonation affording a new family of complexes Cu(Phimp)(H(2)O)(ClO(4))(2) (1), [Cu(Phimp)(2)] (2) and [Cu(Phimp)(L)] (3-5) where L are CH(3)COO(-), SCN(-) and NO(2)(-) respectively. The molecular structures of complexes 1 x CH(3)CN and 3 were determined by X-ray crystallography. Electrochemical studies depicted Cu(II)/Cu(I) couple in the range of -0.50 to -0.65 V vs. Ag/AgCl. EPR spectral studies for complexes 4 and 5 indicated the order of covalent character in 4 > 5 with d(x(2)-y(2)) ground state. Novel copper complexes were synthesized by a tridentate ligand having phenolato, pyridine and azomethine nitrogen donors. Phenoxyl radical complexes were generated; DNA interaction, SOD and nuclease activities were investigated. [corrected]
三齿配体 PhimpH 在去质子化后与 Cu(II)中心配位，形成了一系列新的配合物[Cu(Phimp)(H2O)]2(ClO4)2(1)、Cu(Phimp)2和[Cu(Phimp)(L)]（3-5），其中 L 分别为 CH3COO-、SCN-和 NO2-。配合物 1 x CH3CN 和 3 的分子结构通过 X 射线晶体学确定。电化学研究表明，Cu(II)/Cu(I) 电对的电位范围在-0.50 至-0.65 V 相对于 Ag/AgCl。配合物 4 和 5 的 EPR 光谱研究表明，4 中的共价性质顺序大于 5，其基态为 d(x2-y2)。通过具有苯酚、吡啶和亚甲胺氮供体的三齿配体合成了新型铜配合物。生成了苯氧自由基配合物；研究了 DNA 相互作用、SOD 和核酸酶活性。
