戊巴比妥对γ-氨基丁酸作用的增强

Potentiation of the effects of GABA by pentobarbitone.

作者信息

Evans R H

出版信息

Brain Res. 1979 Jul 27;171(1):113-20. doi: 10.1016/0006-8993(79)90736-4.

Abstract

Pentobarbitone (50 microM) has been shown to potentiate GABA-induced responses in rat isolated superior cervical ganglia and in dorsal or ventral root fibres of immature rat isolated spinal cords. Measurements of dose ratios for the antagonism of GABA-induced responses of dorsal root fibres by bicuculline showed that pentobarbitone (50 microM) did not significantly alter this antagonism. This result indicates that the antagonism of GABA by bucuculline at dorsal root fibres is not reversed by pentobarbitone. Ventral root responses to GABA (but not glycine) were also potentiated by pentobarbitone (+/-)-Nipecotic acid (300 microM) potentiated responses to GABA much more than those to 3-aminopropane-sulphonic acid.

摘要

已表明戊巴比妥（50微摩尔）可增强大鼠离体颈上神经节以及未成熟大鼠离体脊髓背根或腹根纤维中γ-氨基丁酸（GABA）诱导的反应。用荷包牡丹碱拮抗背根纤维中GABA诱导反应的剂量比测量结果表明，戊巴比妥（50微摩尔）并未显著改变这种拮抗作用。该结果表明，戊巴比妥不会逆转荷包牡丹碱对背根纤维中GABA的拮抗作用。戊巴比妥也增强了腹根对GABA（而非甘氨酸）的反应。（±）-尼克酸（300微摩尔）对GABA诱导反应的增强作用远大于对3-氨基丙烷磺酸诱导反应的增强作用。