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Towards rational engineering of cells: Recombinant gene expression in defined chromosomal loci.

作者信息

Nehlsen Kristina, da Gama-Norton Leonor, Schucht Roland, Hauser Hansjörg, Wirth Dagmar

机构信息

Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.

Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany ; Instituto de Tecnologia Química e Biológica-Universidade Nova de Lisboa/Instituto de Biológica Experimental e Tecnológica (ITQB-UNL/IBET), P-2781-901 Oeiras, Portugal.

出版信息

BMC Proc. 2011 Nov 22;5 Suppl 8(Suppl 8):O6. doi: 10.1186/1753-6561-5-S8-O6. eCollection 2011.

DOI:10.1186/1753-6561-5-S8-O6
PMID:22373348
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3284949/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0c5/3284949/ee518d5f3a93/1753-6561-5-S8-O6-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0c5/3284949/ee518d5f3a93/1753-6561-5-S8-O6-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0c5/3284949/ee518d5f3a93/1753-6561-5-S8-O6-1.jpg

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本文引用的文献

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Retroviral vector performance in defined chromosomal Loci of modular packaging cell lines.逆转录病毒载体在模块化包装细胞系定义的染色体基因座中的性能。
Hum Gene Ther. 2010 Aug;21(8):979-91. doi: 10.1089/hum.2009.089.
2
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3
Road to precision: recombinase-based targeting technologies for genome engineering.精准之路：用于基因组工程的基于重组酶的靶向技术
CBX3 普遍染色质开口元件的 CpG 位点是抗沉默功能的关键结构决定因素。
Sci Rep. 2017 Aug 11;7(1):7919. doi: 10.1038/s41598-017-04212-8.
Curr Opin Biotechnol. 2007 Oct;18(5):411-9. doi: 10.1016/j.copbio.2007.07.013. Epub 2007 Sep 27.
4
A new generation of retroviral producer cells: predictable and stable virus production by Flp-mediated site-specific integration of retroviral vectors.新一代逆转录病毒生产细胞：通过Flp介导的逆转录病毒载体位点特异性整合实现可预测且稳定的病毒生产
Mol Ther. 2006 Aug;14(2):285-92. doi: 10.1016/j.ymthe.2005.12.003. Epub 2006 May 11.