Lerch R, Benzi R
Centre de cardiologie, Hôpital cantonal universitaire, Genève.
Schweiz Med Wochenschr. 1990 Oct 20;120(42):1523-30.
Ischemia initiates a cascade of intracellular events that culminates in the death of the myocyte. Reperfusion of ischemic myocardium is the most efficient way of salvaging jeopardized cells. Additional measures referred to as "myocardial protection" may further reduce ischemic injury, primarily by delaying the progression of cellular damage during ischemia. The pathophysiological aspects of ischemic injury and the possibilities for protection of ischemic myocardium are reviewed. In addition to the "established" methods of myocardial protection, the concept of prevention of "reperfusion injury", presently under experimental investigation, is discussed.
缺血引发一系列细胞内事件，最终导致心肌细胞死亡。缺血心肌的再灌注是挽救濒危细胞的最有效方法。被称为“心肌保护”的其他措施可能进一步减轻缺血损伤，主要是通过在缺血期间延缓细胞损伤的进展。本文综述了缺血损伤的病理生理学方面以及保护缺血心肌的可能性。除了“已确立”的心肌保护方法外，还讨论了目前正在实验研究中的预防“再灌注损伤”的概念。
