Department of Organic Chemistry, Slovak University of Technology, Radlinského 9, SK-812 37 Bratislava, Slovakia.
Org Biomol Chem. 2012 Apr 14;10(14):2830-9. doi: 10.1039/c2ob07064b. Epub 2012 Feb 29.
Bi(OTf)(3)·nH(2)O was found to be an efficient promoter of the cyclisative hydroamination of unactivated alkenyl sulfonamides, giving rise to the N-protected 2-methyl pyrrolidines in good to excellent yields (up to 95%). Based on control experiments, a joint Lewis acid-Brønsted acid catalysis might be in operation, or triflic acid itself, generated in situ by hydrolysis of metal triflate, could be the true hydroamination catalyst.
三氟甲磺酸铋（OTf）·nH2O 被发现是一种有效的促进剂，可促进未活化的烯基磺酰胺的环合氢胺化反应，以高产率（高达 95%）得到 N-保护的 2-甲基吡咯烷。基于对照实验，可能存在联合路易斯酸-布朗斯台德酸催化，或者三氟甲磺酸本身可能是真正的氢胺化催化剂，是通过金属三氟甲磺酸酯的水解原位生成的。
