Zain Rosnah Binti, Athirajan Vimmitra, Ghani Wan Maria Nabillah, Razak Ishak Abdul, Raja Latifah Raja Jalaludin, Ismail Siti Mazlipah, Sallam Atiya Abdul, Bustam Anita Zarina, Rahman Zainal Ariff Abdul, Hussien Adam, Talib Norain, Cheong Sok Ching, Jallaludin Amin
Oral Cancer Research and Coordinating Centre, Faculty of Dentistry, University Malaya, 50603, Lembah Pantai, Kuala Lumpur, Malaysia.
Cell Tissue Bank. 2013 Mar;14(1):45-52. doi: 10.1007/s10561-012-9298-0. Epub 2012 Feb 29.
Identification of diagnostic markers for early detection and development of novel and therapeutic agents for effective patient management are the main motivation for cancer research. Biological specimens from large cohort and case-control studies which are crucial in providing successful research outcomes are often the limiting factor that hinders research efforts, especially in developing countries. Therefore, the Malaysian Oral Cancer Database and Tissue Bank System (MOCDTBS) were established to systematically collect large number of samples with comprehensive sociodemographic, clinicopathological, management strategies, quality of life and associated patient follow-up data to facilitate oral cancer research in Malaysia. The MOCDTBS also promotes sharing among researchers and the development of a multidisciplinary research team. The following article aims to describe the process of setting-up and managing the MOCDTBS.
识别用于早期检测的诊断标志物以及开发用于有效管理患者的新型治疗药物是癌症研究的主要动力。来自大型队列研究和病例对照研究的生物标本对于取得成功的研究成果至关重要,但往往是阻碍研究工作的限制因素,尤其是在发展中国家。因此,马来西亚口腔癌数据库和组织库系统(MOCDTBS)得以建立,以便系统地收集大量样本,并附带全面的社会人口统计学、临床病理学、管理策略、生活质量及相关患者随访数据,以促进马来西亚的口腔癌研究。MOCDTBS还促进研究人员之间的共享以及多学科研究团队的发展。以下文章旨在描述MOCDTBS的建立和管理过程。