Vaithilingam R D, Safii S H, Baharuddin N A, Karen-Ng L P, Saub R, Ariffin F, Ramli H, Sharifuddin A, Hidayat M F H, Raman R, Chan Y K, Rani N A, Rahim R A, Shahruddin N, Cheong S C, Bartold P M, Zain R B
Department of Restorative Dentistry, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia.
Oral Dis. 2015 Jan;21(1):e62-9. doi: 10.1111/odi.12267. Epub 2014 Aug 7.
Periodontal bio-repositories, which allow banking of clinically validated human data and biological samples, provide an opportunity to derive biomarkers for periodontal diagnosis, prognosis and therapeutic activities which are expected to improve patient management. This article presents the establishing of the Malaysian Periodontal Database and Biobank System (MPDBS) which was initiated in 2011 with the aim to facilitate periodontal research. Partnerships were established with collaborating centres. Policies on specimen access, authorship and acknowledgement policies were agreed upon by all participating centres before the initiation of the periodontal biobank. Ethical approval for the collection of samples and data were obtained from institutional ethics review boards. A broad-based approach for informed consent was used, which covered areas related to quality of life impacts, genetics and molecular aspects of periodontal disease. Sample collection and processing was performed using a standardized protocol. Biobanking resources such as equipment and freezers were shared with the Malaysian Oral Cancer Database and Tissue Bank System (MOCDTBS). In the development of the MPDBS, challenges that were previously faced by the MOCDTBS were considered. Future challenges in terms of ethical and legal issues will be faced when international collaborations necessitate the transportation of specimens across borders.
牙周生物样本库能够储存经过临床验证的人类数据和生物样本，为牙周诊断、预后评估及治疗活动提供了获取生物标志物的机会，有望改善患者管理。本文介绍了马来西亚牙周数据库与生物样本库系统（MPDBS）的建立情况，该系统于2011年启动，旨在推动牙周研究。与合作中心建立了伙伴关系。在牙周生物样本库启动之前，所有参与中心就样本获取政策、作者身份及致谢政策达成了一致。从机构伦理审查委员会获得了样本和数据收集的伦理批准。采用了涵盖生活质量影响、牙周病遗传学和分子方面等相关领域的广泛知情同意方法。样本收集和处理按照标准化方案进行。生物样本库资源，如设备和冰柜，与马来西亚口腔癌数据库和组织库系统（MOCDTBS）共享。在MPDBS的开发过程中，考虑了MOCDTBS此前面临的挑战。当国际合作需要跨境运输样本时，未来将面临伦理和法律问题方面的挑战。
