Faculty of Medicine, University of Antwerp, Antwerpen, Belgium.
Kidney Int. 2012 Mar;81(6):513-5. doi: 10.1038/ki.2011.428.
Chinese herbs nephropathy (CHN) and Balkan endemic nephropathy (BEN) are chronic tubulointerstitial renal diseases associated with urothelial carcinoma. The clinical expression and pathological lesions observed at different stages of CHN and BEN are strikingly similar. Both have been linked to exposure to aristolochic acid (AA), a powerful nephrotoxin and human carcinogen. Jelaković et al. present molecular epidemiological evidence relating urothelial carcinoma in patients with BEN to dietary exposure to AA. It is time to abandon the terms 'CHN' and 'BEN' and introduce 'aristolochic acid nephropathy' to cover both clinical conditions.
中草药肾病（CHN）和巴尔干地方性肾病（BEN）是与尿路上皮癌相关的慢性肾小管间质性肾脏疾病。CHN 和 BEN 的不同阶段观察到的临床表型和病理损伤具有惊人的相似性。两者均与马兜铃酸（AA）暴露有关，AA 是一种强大的肾毒素和人类致癌物。Jelaković 等人提出了分子流行病学证据，表明 BEN 患者的尿路上皮癌与 AA 的饮食暴露有关。是时候摒弃“CHN”和“BEN”这两个术语，引入“马兜铃酸肾病”来涵盖这两种临床情况了。
