Department of Molecular Medicine, Laboratory of Virology, "Sapienza" University of Rome, Italy.
Virus Res. 2012 May;165(2):236-40. doi: 10.1016/j.virusres.2012.02.018. Epub 2012 Feb 25.
The genetic diversity of the host is believed to be the key of the diversity in the clinical presentation of bronchiolitis. The aim of this study was to determine whether the known rs12979860 and rs8099917 single nucleotide polymorphisms (SNPs) in interleukin (IL)28B region, influence clinical features and natural history of bronchiolitis. Both SNPs showed no significant association with the risk of hospitalization for respiratory syncytial virus (RSV), viral load, disease severity, and other clinical features of patients. Interestingly infants carrying IL28B rs12979860 TT genotype had lower age at hospital admission than that of infants carrying CC/CT genotypes. Overall our results indicate that both IL28B SNPs had no impact on the clinical course of bronchiolitis with the only exception of the IL28B rs12979860 SNP which increased the risk of hospitalization for bronchiolitis at early age.
宿主的遗传多样性被认为是毛细支气管炎临床表现多样性的关键。本研究旨在确定白细胞介素（IL）28B 区域中已知的 rs12979860 和 rs8099917 单核苷酸多态性（SNP）是否影响毛细支气管炎的临床特征和自然病程。这两个 SNP 与呼吸道合胞病毒（RSV）住院风险、病毒载量、疾病严重程度和患者的其他临床特征均无显著相关性。有趣的是，携带 IL28B rs12979860 TT 基因型的婴儿的住院年龄低于携带 CC/CT 基因型的婴儿。总的来说，我们的研究结果表明，IL28B 这两个 SNP 均不会影响毛细支气管炎的临床病程，只有 IL28B rs12979860 SNP 是个例外，它增加了毛细支气管炎患儿的早期住院风险。
