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大鼠下丘脑腹内侧核至额叶皮质的单突触易化通路。

Monosynaptic facilitatory pathway from the hypothalamic ventromedial nucleus to the frontal cortex in the rat.

作者信息

Ohta M, Oomura Y

出版信息

Brain Res Bull. 1979 Mar-Apr;4(2):223-9. doi: 10.1016/0361-9230(79)90286-7.

DOI:10.1016/0361-9230(79)90286-7
PMID:223745
Abstract

Stimulation of the ventromedial nucleus (VMH) evoked a short latency negative wave with two peaks (cN1 and cN2) followed by a small positive wave (cP) at the ipsilateral dorsal frontal cortex (area 10) in the rat. The maximum response was observed from the lateral edge of the frontal pole. From the depth profiles of recordings, cN1 changed polarity at a depth of about 4 mm and the cN1-cN2 changed into a large compound action potential at the medioventral part of the frontal pole at a depth of about 6 mm. Since the surface evoked potential and the compound action potential followed high frequency stimulation, these respective potentials are concluded to be due to antidromic and monosynaptic activation of the cortical neurons. This was verified by unit recording experiments. The cP was concluded to be produced by the initial rise of the monosynaptic EPSP.

摘要

刺激大鼠腹内侧核(VMH)会在同侧背侧额叶皮质(10区)诱发一个潜伏期短的负波,有两个峰值(cN1和cN2),随后是一个小的正波(cP)。最大反应出现在额极的外侧边缘。从记录的深度剖面图来看,cN1在约4毫米深度处极性发生改变,cN1 - cN2在约6毫米深度处的额极腹内侧部分转变为一个大的复合动作电位。由于表面诱发电位和复合动作电位跟随高频刺激,因此得出这些电位分别是由于皮质神经元的逆向和单突触激活所致。这通过单位记录实验得到了验证。cP被认为是由单突触兴奋性突触后电位(EPSP)的初始上升产生的。

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