Ohta M, Oomura Y
Brain Res Bull. 1979 Mar-Apr;4(2):231-8. doi: 10.1016/0361-9230(79)90287-9.
Stimulation of the dorsal frontal cortex (area 10, FCtx) evoked two negative waves with short latencies (N1 and N2) followed by a large, longlasting positive wave (P) in the ventromedial nucleus (VMH) as well as in the more dorsal structures in the hypothalamus and the ventral thalamus. Since the N1 followed high frequency stimulation, it was concluded to be due to antidromic activity. Double or triple pulse stimulation summated the P, and reduced the amplitude of the negative waves of the second and the third responses. VMH neuronal discharges were also decreased during the time course of the P. Therefore, the P was concluded to be composed of the IPSPs. VMH neuronal discharges were frequently superimposed on the N2, indicating the origin of this wave to be EPSPs. Strychnine reduced or blocked the inhibition of the VMH neurons caused by not only FCtx stimulation but also glycine application. The results indicate that the VMH receives both excitatory and inhibitory projections from the FCtx, and the inhibition may be transmitted by glycine.
刺激背侧额叶皮质（第10区，额叶皮质）会诱发两个潜伏期较短的负波（N1和N2），随后在腹内侧核（VMH）以及下丘脑和腹侧丘脑背侧结构中出现一个大的、持续时间长的正波（P）。由于N1跟随高频刺激出现，因此推断它是由逆向活动引起的。双脉冲或三脉冲刺激使P波叠加，并降低了第二个和第三个反应的负波幅度。在P波的时间进程中，VMH神经元放电也减少。因此，推断P波由抑制性突触后电位（IPSPs）组成。VMH神经元放电经常叠加在N2上，表明该波起源于兴奋性突触后电位（EPSPs）。士的宁不仅能减少或阻断由额叶皮质刺激引起的VMH神经元抑制，还能减少或阻断由甘氨酸应用引起的抑制。结果表明，VMH接受来自额叶皮质的兴奋性和抑制性投射，并且这种抑制可能由甘氨酸传递。
