Department of Pathology, School of Medicine, Tsinghua University, Beijng, China.
J Zhejiang Univ Sci B. 2012 Mar;13(3):168-75. doi: 10.1631/jzus.B1100077.
In this study, we investigated the interrelationship between clinicopathologic findings and pre-B-cell leukemia transcription factor 2 (PBX2) expression in gingival squamous cell carcinoma (GSCC).
Expression level of PBX2 was immunohistochemically examined in 66 GSCC subjects (30 men and 36 women) with ages ranging from 42 to 85 (median 64.5) years, in which staining intensity in tumor cells was categorized as either weaker (level 1) or equal to/stronger (level 2) than that in the endothelial cells.
PBX2 expression is correlated with valosin-containing protein (VCP) expression. Univariate and multivariate analyses revealed a high level of PBX2 expression to be a poor prognosticator for disease-free survival (DFS) and overall survival (OS), and PBX2 expression was an independent prognostic factor for both DFS and OS in GSCC.
PBX2 expression level in GSCC is prognostic. PBX2 may be a useful marker to identify the potential for progression in GSCC.
本研究旨在探讨牙龈鳞状细胞癌（GSCC）中临床病理表现与前 B 细胞白血病转录因子 2（PBX2）表达之间的相互关系。
对 66 例 GSCC 患者（男 30 例，女 36 例）的 PBX2 表达水平进行免疫组织化学检测，患者年龄 42-85 岁，中位年龄 64.5 岁。肿瘤细胞的染色强度分为弱于（1 级）或等于/强于（2 级）内皮细胞。
PBX2 表达与泛素结合酶 E3 成分 N-识别蛋白（VCP）表达相关。单因素和多因素分析显示，高水平 PBX2 表达是疾病无进展生存期（DFS）和总生存期（OS）的不良预后因素，PBX2 表达是 GSCC 患者 DFS 和 OS 的独立预后因素。
GSCC 中 PBX2 的表达水平具有预后意义。PBX2 可能是识别 GSCC 进展潜能的有用标志物。
