Department of Diabetes, Endocrinology and Metabolism, Hammersmith Campus, Imperial College London, London, UK.
Gut Liver. 2012 Jan;6(1):10-20. doi: 10.5009/gnl.2012.6.1.10. Epub 2012 Jan 12.
The global obesity epidemic has resulted in significant morbidity and mortality. However, the medical treatment of obesity is limited. Gastric bypass is an effective surgical treatment but carries significant perioperative risks. The gut hormones, peptide tyrosine tyrosine (PYY) and glucagon-like peptide 1 (GLP-1), are elevated following gastric bypass and have been shown to reduce food intake. They may provide new therapeutic targets. This review article provides an overview of the central control of food intake and the role of PYY and GLP-1 in appetite control. Key translational animal and human studies are reviewed.
全球肥胖症流行导致了大量的发病率和死亡率。然而，肥胖症的治疗方法有限。胃旁路手术是一种有效的手术治疗方法，但有显著的围手术期风险。胃旁路手术后，肠激素肽 YY（PYY）和胰高血糖素样肽 1（GLP-1）水平升高，已被证明可减少食物摄入。它们可能为治疗提供新的靶点。本文综述了摄食的中枢控制以及 PYY 和 GLP-1 在食欲控制中的作用，并对关键的转化动物和人体研究进行了回顾。
