Hijová Emília, Bertková Izabela, Štofilová Jana
Center of Clinical and Preclinical Research-MediPark, Faculty of Medicine, Pavol Jozef Šafárik University, SNP 1, 040 11 Košice, Slovakia.
Int J Mol Sci. 2025 Jun 3;26(11):5362. doi: 10.3390/ijms26115362.
Obesity is reaching global epidemic proportions worldwide, posing a significant burden on individual health and society. Altered gut microbiota is considered a key factor in the pathogenesis of many diseases, producing metabolites that contribute to the health-beneficial properties of postbiotics. Postbiotics, bioactive microbial components derived from probiotics, are emerging as a valuable strategy in modern medicine and a promising alternative for managing obesity without the need for live bacteria. This work provides a comprehensive overview of the potential health benefits of postbiotics, particularly in relation to obesity, which represents an important health challenge. Despite the encouraging insights into the health benefits of postbiotics, we highlight the need for further research to clarify the mechanisms and the specific roles of different postbiotic components. Integrating postbiotics into health interventions has the potential to enhance preventive care and significantly improve health outcomes in at-risk populations.
肥胖在全球范围内正达到流行程度，给个人健康和社会带来重大负担。肠道微生物群的改变被认为是许多疾病发病机制中的关键因素，其产生的代谢产物有助于后生元的有益健康特性。后生元是源自益生菌的生物活性微生物成分，正成为现代医学中有价值的策略，也是无需活菌来管理肥胖的有前景的替代方法。这项工作全面概述了后生元的潜在健康益处，特别是与肥胖相关的益处，肥胖是一项重要的健康挑战。尽管后生元对健康有益的见解令人鼓舞，但我们强调需要进一步研究以阐明机制以及不同后生元成分的具体作用。将后生元纳入健康干预措施有可能加强预防保健并显著改善高危人群的健康结果。
