McManus D P
Tropical Health Program, Queensland Institute of Medical Research, Brisbane, Australia.
Southeast Asian J Trop Med Public Health. 1990 Jun;21(2):161-73.
Recombinant DNA and related technologies are providing valuable, novel reagents for application in control strategies against the major parasitic diseases, including hydatid disease and cysticercosis. The impact of these powerful techniques for improving diagnosis and identification of various life cycle stages of Echinococcus spp. and Taenia solium, essential pre-requisites for epidemiological studies and for evaluating control programs, is beyond question. Furthermore, the use of molecular technology for characterizing sub-specific variants of strains of both Echinococcus and T. solium has led to important revisions of our understanding of the diseases they cause. In light of the recent remarkable development of a recombinant vaccine against T. ovis, the first practical parasite vaccine to be produced, the prospects for rapid development of similar vaccines against the medically important taeniids appear to be very encouraging.
重组DNA及相关技术正在提供有价值的新型试剂，用于应对包括包虫病和囊尾蚴病在内的主要寄生虫病的控制策略。这些强大技术对改进棘球绦虫属和猪带绦虫各个生命周期阶段的诊断和鉴定的影响，对于流行病学研究和评估控制项目而言是必不可少的先决条件，这是毋庸置疑的。此外，利用分子技术对棘球绦虫和猪带绦虫菌株的亚特异性变体进行表征，已使我们对它们所引起疾病的认识有了重要修正。鉴于最近针对绵羊绦虫研制出了第一种实用的寄生虫重组疫苗，且该疫苗已取得显著进展，因此针对具有医学重要性的带绦虫研制类似疫苗的快速发展前景似乎非常乐观。
