Lightowlers M W
University of Melbourne, Veterinary Clinical Centre, Werribee, Australia.
Acta Leiden. 1989;57(2):135-42.
Progress in recent research towards vaccination against cysticercosis is reviewed briefly. An antigen of Taenia ovis has recently been cloned using recombinant DNA techniques and this single defined recombinant molecule has been shown to induce high-level protection against challenge infection in sheep. Prospects for the application of this discovery in T. ovis for development of effective vaccines against infection with the metacestodes of other taeniid parasites are discussed. The extent and level of cross protection between different taeniid species is reviewed. Recent research results defining stage-specific immune responses against T. taeniaeformis in mice following immunization with oncosphere and metacestode antigens is discussed in relation to the potential development of cocktail vaccines. Such vaccines may be capable of protecting against initial infection and the killing of those parasites which might evade the early-phase immune responses. Recent advances in the development of a practical vaccine against Taenia ovis infection in sheep raise the realistic prospect of the development of a similar vaccine against other taeniid parasites including T. solium. Advances in the understanding of vaccination - induced immune responses against T. taeniaeformis infection in mice also indicate that effective immunization may be capable of eliminating the establishment of any viable metacestodes.
本文简要综述了近期猪囊尾蚴病疫苗研究的进展。最近利用重组DNA技术克隆了绵羊带绦虫的一种抗原，这种单一的确定重组分子已被证明能在绵羊中诱导高水平的保护以抵抗攻击感染。讨论了将这一发现应用于绵羊带绦虫以开发针对其他带科寄生虫的囊尾蚴感染的有效疫苗的前景。综述了不同带科物种之间交叉保护的程度和水平。讨论了近期关于用六钩蚴和囊尾蚴抗原免疫小鼠后对带状带绦虫的阶段特异性免疫反应的研究结果，这些结果与联合疫苗的潜在开发有关。这种疫苗可能能够预防初始感染，并杀死那些可能逃避早期免疫反应的寄生虫。针对绵羊带绦虫感染的实用疫苗开发的最新进展，提高了开发针对包括猪带绦虫在内的其他带科寄生虫的类似疫苗的现实前景。对小鼠中针对带状带绦虫感染的疫苗诱导免疫反应的理解进展也表明，有效的免疫接种可能能够消除任何活的囊尾蚴的建立。
