UNESP-Univ. Estadual Paulista, School of Dentistry, Department of Diagnosis and Surgery, Division of Periodontology, Rua Humaitá, 1680, 14801-903 Araraquara, SP, Brazil.
Head Face Med. 2012 Mar 1;8:5. doi: 10.1186/1746-160X-8-5.
This literature review aims to evaluate the epidemiologic profile of patients with rheumatoid arthritis (RA) that developed a bisphosphonate-related osteonecrosis that affect the jaws (BRONJ), including demographic aspects, as well as clinical and therapeutic issues. A search of PUBMED/MEDLINE, Scopus, and Cochrane databases from January 2003 to September 2011 was conducted with the objective of identifying publications that contained case reports regarding oral BRONJ in RA patients. Patients with RA who develop oral BRONJ are usually women above 60 years taking steroids and long-term alendronate. Most of them have osteoporosis, and lesions, triggered by dental procedures, are usually detected at stage II in the mandible. Although there is no accepted treatment protocol, these patients seem to have better outcomes with conservative approaches that include antibiotic therapy, chlorhexidine, and drug discontinuation.
本文献综述旨在评估类风湿关节炎（RA）患者发生影响颌骨的双膦酸盐相关性骨坏死（BRONJ）的流行病学特征，包括人口统计学方面以及临床和治疗问题。从 2003 年 1 月至 2011 年 9 月，对 PUBMED/MEDLINE、Scopus 和 Cochrane 数据库进行了检索，目的是确定包含 RA 患者口腔 BRONJ 病例报告的出版物。发生口腔 BRONJ 的 RA 患者通常为 60 岁以上服用类固醇和长期阿伦膦酸盐的女性。他们大多数患有骨质疏松症，由牙科手术引发的病变通常在颌骨的 II 期被发现。尽管目前尚无公认的治疗方案，但对于采用包括抗生素治疗、洗必泰以及药物停用的保守方法，这些患者的预后似乎更好。
