Paek Seung Jae, Park Won-Jong, Shin Ho-Sung, Choi Moon-Gi, Kwon Kyung-Hwan, Choi Eun Joo
Department of Oral and Maxillofacial Surgery, Wonkwang University Dental Hospital, Wonkwang University, Iksan, Korea.
Department of Oral and Maxillofacial Surgery, College of Dentistry, Wonkwang University, Iksan, Korea.
J Korean Assoc Oral Maxillofac Surg. 2016 Oct;42(5):271-277. doi: 10.5125/jkaoms.2016.42.5.271. Epub 2016 Oct 25.
The objective of this study was to retrospectively investigate the association of diseases having an influence on inhibition of angiogenesis such as hypertension, diabetes mellitus type II, hypercholesterolemia, and rheumatoid arthritis (RA) with the development of osteonecrosis of the jaws.
The 135 patients were allocated into 4 groups of bisphosphonate-related osteonecrosis of the jaw (BRONJ) group (1A); non-BRONJ group (1B); osteonecrosis of the jaw (ONJ) group (2A); and control group (2B), according to histologic results and use of bisphosphonate. This retrospective study was conducted with patients who were treated in one institute from 2012 to 2013. Fisher's exact test and logistic regression analysis were used to analyze the odds ratios of diseases having an influence on inhibition of angiogenesis for development of ONJ.
The effects of diabetes and hypertension were not statistically significant on development of ONJ. When not considering bisphosphonate use, RA exhibited a high odds ratio of 3.23 (=0.094), while hyperlipidemia showed an odds ratio of 2.10 (=0.144) for development of ONJ. More than one disease that had an influence on inhibition of angiogenesis showed a statistically significant odds ratio of 2.54 (=0.012) for development of ONJ.
Patients without diseases having an influence on inhibition of angiogenesis were at less risk for developing ONJ.
本研究的目的是回顾性调查高血压、II型糖尿病、高胆固醇血症和类风湿性关节炎（RA）等影响血管生成抑制的疾病与颌骨坏死发生之间的关联。
根据组织学结果和双膦酸盐的使用情况，将135例患者分为4组：双膦酸盐相关颌骨坏死（BRONJ）组（1A）；非BRONJ组（1B）；颌骨坏死（ONJ）组（2A）；以及对照组（2B）。本回顾性研究针对2012年至2013年在一家机构接受治疗的患者进行。采用Fisher精确检验和逻辑回归分析来分析影响血管生成抑制的疾病对ONJ发生的比值比。
糖尿病和高血压对ONJ发生的影响无统计学意义。在不考虑双膦酸盐使用的情况下，RA发生ONJ的比值比为3.23（=0.094），而高脂血症的比值比为2.10（=0.144）。一种以上影响血管生成抑制的疾病发生ONJ的比值比为2.54（=0.012），具有统计学意义。
没有影响血管生成抑制疾病的患者发生ONJ的风险较低。
