Department of Obstetrics and Gynaecology, Faculty of Medicine, Kuwait University, Safat, Kuwait.
Reprod Biomed Online. 2012 Apr;24(4):381-8. doi: 10.1016/j.rbmo.2012.01.010. Epub 2012 Jan 24.
There is an ongoing debate regarding the impact of premature progesterone rise on the IVF outcome. The objective of this review is to assess evidence of poorer ongoing pregnancy rate in IVF cycles with elevated serum progesterone at the end of follicular phase in ovarian stimulation. It also explores the origin of the progesterone rise, potential modifying factors and possible methods to prevent its rise during ovarian stimulation. This review draws on information already published from monitoring progesterone concentrations at the end of follicular phase in ovarian stimulation. The databases of Medline and PubMed were searched to identify relevant publications. Good-quality evidence supports the negative impact on endometrial receptivity of elevated progesterone concentrations at the end of the follicular phase in ovarian stimulation. Future trials should document the cause and origin of premature progesterone in stimulated IVF cycles. There is an ongoing debate regarding the impact of premature progesterone rise on the IVF outcome. The objective of this review is to assess evidence of poorer ongoing pregnancy rate in IVF cycles with elevated serum progesterone at the end of follicular phase in ovarian stimulation. It also explores the origin of the progesterone rise, potential modifying factors and possible methods to prevent its rise during ovarian stimulation. This review draws on information already published from monitoring progesterone concentrations at the end of follicular phase in ovarian stimulation. The databases of Medline and PubMed were searched to identify relevant publications. Good-quality evidence supports the negative impact on endometrial receptivity of elevated progesterone concentrations at the end of follicular phase in ovarian stimulation. Future trials should document the cause and origin of premature progesterone in stimulated IVF cycles.
关于孕激素过早升高对试管婴儿结局的影响，一直存在争议。本综述旨在评估卵巢刺激卵泡期末血清孕激素升高对试管婴儿持续妊娠率的影响，并探讨孕激素升高的原因、潜在的调节因素以及在卵巢刺激过程中预防其升高的可能方法。本综述基于卵巢刺激卵泡期末监测孕激素浓度的已发表信息。检索了 Medline 和 PubMed 数据库，以确定相关的出版物。高质量的证据支持卵巢刺激卵泡期末孕激素浓度升高对子宫内膜容受性的负面影响。未来的试验应记录刺激试管婴儿周期中孕激素过早升高的原因和来源。
