Schultz S, Kane M, Roush R, Miller V, Berd D, Goldman L, Mastrangelo M
Memorial Clinic of Indianapolis, Indiana.
Surg Gynecol Obstet. 1990 Nov;171(5):393-7.
The thickness of a tumor has been identified as the principal prognostic factor in cutaneous malignant melanoma. However, time to recurrence has not conclusively been related to thickness. A retrospective study of 216 patients with a primary cutaneous malignant melanoma that recurred was conducted to clarify this relationship and investigate possible independent relationships between age at diagnosis and sex of patients to time to recurrence. The results of analysis of linear regression revealed an inverse linear relationship between thickness and time to recurrence (p less than 0.001). Patients more than 50 years of age at the time of diagnosis were shown to relapse sooner than those less than 50 years of age (p = 0.014). Sex was not a significant factor in predicting time to recurrence (p greater than 0.10). These results suggest that thickness of tumor provides an indication of time to recurrence in those patients destined to recur and stress the need for long term surveillance in patients with a history of malignant melanoma because of the possibility of late relapse even with thin lesions.
肿瘤厚度已被确定为皮肤恶性黑色素瘤的主要预后因素。然而，复发时间与肿瘤厚度之间尚未明确建立关联。开展了一项针对216例原发性皮肤恶性黑色素瘤复发患者的回顾性研究，以阐明这种关系，并探究患者诊断时的年龄和性别与复发时间之间可能存在的独立关系。线性回归分析结果显示，肿瘤厚度与复发时间呈负线性关系（p<0.001）。诊断时年龄超过50岁的患者比年龄小于50岁的患者复发更早（p = 0.014）。性别并非预测复发时间的显著因素（p>0.10）。这些结果表明，肿瘤厚度可为注定会复发的患者提供复发时间的指征，并强调对于有恶性黑色素瘤病史的患者进行长期监测的必要性，因为即使是薄病变也可能出现晚期复发。
