Toronto Western Research Institute, University Health Network, and University of Toronto, Canada.
Curr Opin Neurobiol. 2012 Aug;22(4):660-9. doi: 10.1016/j.conb.2012.02.001. Epub 2012 Feb 28.
Oscillatory, population activities have long been known to occur in our brains during different behavioral states. We know that many different cell types exist and that they contribute in distinct ways to the generation of these activities. I review recent papers that involve cellular-based models of brain networks, most of which include theta, gamma and sharp wave-ripple activities. To help organize the modeling work, I present it from a perspective of three different types of cellular-based modeling: 'Generic', 'Biophysical' and 'Linking'. Cellular-based modeling is taken to encompass the four features of experiment, model development, theory/analyses, and model usage/computation. The three modeling types are shown to include these features and interactions in different ways.
振荡、群体活动长期以来一直被认为存在于我们大脑的不同行为状态中。我们知道存在许多不同的细胞类型，它们以不同的方式促成这些活动的产生。我回顾了最近涉及基于细胞的脑网络模型的论文，其中大多数包括θ波、γ波和锐波涟漪活动。为了帮助组织建模工作，我从三种不同类型的基于细胞的建模的角度来呈现：“通用型”、“生物物理型”和“连接型”。基于细胞的建模被认为包含实验、模型开发、理论/分析以及模型使用/计算这四个特征。这三种建模类型以不同的方式包含这些特征和相互作用。
